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ICSI Manchester

ICSI Manchester
ICSI & IVF in Manchester

ICSI Manchester


Intra-Cytoplasmic Sperm Injection (ICSI) falls under the umbrella term of ‘assisted conception’. ICSI is a newer technique, with the first child was born in Singapore in April 1989. ICSI is a similar treatment to IVF however the main difference between IVF and ICSI is that in IVF, nature is mimicked by adding a large number of sperm to a dish with a number of eggs, with the hope of fertilisation by the strongest sperm. In ICSI, a single sperm is injected directly into the egg to fertilise.

ICSI Manchester


What is ICSI?

Intra-Cytoplasmic Sperm Injection (ICSI) refers to the technique of injecting a single sperm into the centre (cytoplasm) of the egg.

Why is ICSI necessary?

This method overcomes problems of failed or abnormal fertilisation by placing a single sperm directly in the centre of the egg. Problems arise when the sperm may not be the ‘right’ one, or because the injection procedure damages the egg. ICSI is relatively new and as such should still be regarded as experimental. If you would like to discuss ICSI in Manchester, get in touch today.

How is ICSI carried out?

On the day of the procedure, the embryologist carefully removes the outer cells from each egg, using an enzyme normally produced by sperm. All eggs can be inseminated by IVF, but only mature eggs can be used in ICSI. The sperm are prepared as normal, the embryologist then picks out individual live sperm, and injects one into each egg, using a special glass needle. After ICSI the eggs are returned to the incubator overnight and checked for fertilisation the following morning, as for conventional IVF. Our specialist team at Aurora Healthcare are expertly trained and qualified in performing ICSI in Manchester so please feel free to contact us for help and advice.

Who is ICSI for?

We currently use ICSI in couples with reduced semen counts or where there is reduced sperm motility, in which the risk of fertilisation failure is increased, and also those who have previously had very low or no fertilisation in an IVF cycle.

-Sperm concentration less than 15 X 106/ml
-Progressive sperm motility (categories a+b) less than 32%
-Normal sperm morphology less than 2%
-Reduced fertilIsation rate after conventional IVF: <40% normal fertilisation with at least 4 mature eggs collected
-Failed fertilisation after conventional IVF
-Use of Epididymal/Testicular sperm
-Use of frozen stored sperm (this is not mandatory but we do recommend it in certain situations)
-Patients who have had ICSI in previous IVF cycles should continue to do so in future cycles

What Risks Are Associated With ICSI?

ICSI is still a relatively new technique and was not preceded by long-term animal studies, as is usually required for new medical techniques or drugs. It is known that abnormal sperm production (very low sperm count or absent sperm in the ejaculate), can be associated with genetic defects in the male. As ICSI bypasses the normal processes of sperm ‘selection’ and fertilisation, these genetic defects may be transmitted to the children. In rare cases, the egg is damaged by the injection procedure. This can result in damage to the resulting embryo.

The full implications of ICSI treatment will not be known for many years, and you should be aware of the possible risks of this procedure as detailed below.

Chromosomal Abnormalities


Between 3-5% of men with very low sperm counts are more likely to have a rearrangement of their chromosomes responsible for sex determination in babies – known as a balanced translocation. A rearrangement can lead to a chromosome abnormality in any baby conceived. Some men with low sperm counts will have a small deletion of a portion of their Y chromosome i.e. a tiny genetic fragment may be missing. This will not be found in routine chromosome testing. This deletion may be passed on to a baby boy and may cause him to have a lowered sperm count when he grows up.

What happens if your chromosome test shows a rearrangement?

If an abnormality is found, the chance of a pregnancy is less and may increase the chance of miscarriage. The child may be unaffected, but if an abnormality is found in your chromosomes, this your Consultant will discuss everything with you and you would be referred to the Regional Genetics service for further counselling.

Birth Defects


The evidence on whether or not babies born after IVF or ICSI treatment have a greater risk of birth defects is not yet completely clear, and more studies are needed in order to gain further insight into these possible effects. In 2005, a major European review of children born after ICSI and IVF (followed up until age 5) found that major birth defects involving the heart, lungs, musculoskeletal or gastrointestinal systems, were present in about 2% of naturally conceived offspring, 4% of children conceived by routine IVF, and in 6% of children conceived after ICSI. A substantial proportion of the abnormalities in the ICSI children were problems in the development of the urinary or genital organs, especially in boys. However, all of them were correctable by surgery and they reflected paternal genetic factors rather than the procedure itself. Minor birth defects were present in about 20% of naturally conceived offspring, 31% of children conceived by routine IVF, and in 29% of children conceived after ICSI. Minor anomalies are those which do not have serious medical, functional or cosmetic consequences for the child. More recent studies reported no difference in the risk for any anomaly or specific anomalies after different types of IVF technologies including ICSI.

Developmental Delay


Some research papers on follow ups of small numbers of ICSI children suggest possible developmental delay in some children conceived using the ICSI technique. This has not been found in ongoing follow up studies in the UK and Europe.

As with all of our services, if you have any questions or concerns you would like to discuss further, you will have the opportunity to do so at any clinic appointment.

ICSI Treatment Success Rates


Approximately 6 out of every 10 eggs will fertilise successfully with ICSI, similar to IVF. The reasons ICSI fertilisation is not 100% successful are:

-Immature eggs cannot be injected
-Some eggs may be damaged by the injection procedure. This appears to be related to the properties of the inner egg membrane.
-Even when injected directly into the egg, many sperm are not capable of ‘activating’ and fertilising the egg.

After successful fertilisation, embryo development is similar for both methods. Following embryo transfer, pregnancy rates are similar for both procedures. Many clinics report higher success rates for ICSI compared to IVF, but this is only because the women having ICSI are relatively more fertile.


For Professional, Affordable ICSI & IVF in Manchester & Across The North West, Contact Aurora Healthcare Today


If you are considering exploring assisted conception and IVF in Manchester, we are here for you. At our Manchester fertility clinic here at Aurora Healthcare, we have many years’ experience with specialised fertility treatments to increase your chances of a successful outcome. To discuss assisted conception and the most suitable fertility treatments for you, please get in touch with our team today.

You can call us directly on 0161 244 8623 or alternatively, please fill in our online contact form and we will contact you. 

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