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Implantation Failure

implantation failure manchester

Embryo Implantation 

If you have experienced implantation failure in Manchester or the surrounding areas, we are here to help you. 

The embryo generated from the egg and sperm during IVF needs to embed (implant) into the lining of a woman’s womb for pregnancy to take place. The chance of an embryo successfully implanting is only approximately 30%, meaning the chance of an embryo failing to implant is approximately 70%. The chance of pregnancy increases slightly with increasing numbers of transferred embryos such that the chance of two embryos failing to implant is 49%. Although this may sound low, most women will have successfully achieved a pregnancy by their third cycle of IVF.

Recurrent Implantation Failure

Should this not be the case, there may be an underlying problem causing the lack of pregnancy. Recurrent implantation failure (RIF) is therefore generally defined as the absence of pregnancy (embryo implantation) following three transfers of good quality embryos in IVF cycles.

Causes Of Implantation Failure 

Many factors determine whether pregnancy occurs in an IVF cycle including:

Embryo Factors

Quality of the embryo: one important variable is clearly the quality of the embryo as a poor quality embryo is less likely to implant and lead to pregnancy. A good-quality embryo is one that has the correct number of normal cells corresponding to the day of its development.

There is no widespread agreement on the number of embryos transferred that qualify for the definition of RIF, but most specialists would agree to apply the definition after three unsuccessful embryo implantation procedures.

Maternal Age

The age of the woman is probably the most important determinant of the chance of pregnancy following an IVF cycle. Embryo quality is closely related to maternal age.

Uterine Factors

Inherited or acquired abnormalities of the womb can contribute to RIF including:

  • Uterine fibroids (the closer the fibroid is to the lining of the womb the greater its impact)
  • Polyps in the lining of the womb
  • Inflammation of the lining of the womb
  • Abnormal shape of the lining of the womb (Septate uterus)
  • Adhesions in the lining of the womb
  • Uterine endometriosis (adenomyosis)
Endometrial Factors

Reduced endometrial receptivity such as:

  • Thin endometrium
  • Altered expression of adhesive molecules
  • Immunological factors affecting the endometrium

If You Wish To Discuss Implantation Failure in Manchester With Fertility Experts, Call Us Today

If you have experienced implantation failure, we are here for you. At Aurora Healthcare, we have an expert team of fertility specialists and access to industry-leading medical equipment, reassuring you that you are in safe, professional hands. For help and advice with fertility, or to arrange your confidential consultation, get in touch with our team today.

Please call us directly on 0161 244 8623 or alternatively, fill in our online contact form and a member of our team will be in touch. 

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